Opportunity Information: Apply for PAR 18 095
The National Institutes of Health (NIH) funding opportunity PAR 18 095, titled "Research to Advance the Understanding and Management of the Multiple Organ Dysfunction Syndrome in Children (R03 Clinical Trial Optional)," supports small, targeted research projects that can move the field forward on pediatric multiple organ dysfunction syndrome (MODS). MODS is a serious and often life-threatening condition in which multiple organ systems fail during critical illness, and it remains a major driver of morbidity and mortality in children. The central goal of this opportunity is to deepen scientific and clinical understanding of MODS in children so researchers can identify better ways to prevent it, recognize it earlier, and treat it more effectively. NIH is explicitly signaling that, despite how common and devastating MODS can be in pediatric care, the evidence base is still limited and there is a strong need for diverse types of studies that clarify mechanisms, risk factors, trajectories, and management strategies.
This opportunity uses the NIH R03 mechanism, which is designed for exploratory or developmental projects that are smaller in scale than an R01. In practice, that means the program is well-suited for pilot studies, feasibility work, early-stage hypothesis testing, preliminary data generation, method development, or focused analyses that can quickly answer a defined question and set up a stronger future application. NIH also indicates that the work funded here is intended to inform subsequent R01 proposals, which makes the program particularly relevant for teams that have a promising idea but need initial data, proof-of-concept results, or refined approaches before attempting a larger multi-year grant. The notice "Clinical Trial Optional" means applicants may propose clinical trials if appropriate, but they are not required to do so; non-trial studies such as observational research, translational studies, data-driven analyses, or foundational biological investigations can also fit the intent as long as they clearly advance pediatric MODS understanding or management.
From a funding details standpoint, this is a discretionary grant program under the Health, Income Security and Social Services activity category, listed under CFDA 93.865. The award ceiling in the provided source data is $50,000, indicating that NIH is emphasizing modest-budget projects with clearly defined deliverables rather than large, resource-intensive studies. The original closing date listed is 2019-05-07, and the opportunity record shows a creation date of 2017-11-06. While those dates suggest this particular posting may be historical, the program description still provides a clear picture of NIH priorities around pediatric MODS research: generating actionable knowledge that can translate into better clinical outcomes, including both prevention and treatment.
Eligibility is broad and includes many types of U.S. organizations and government entities. Eligible applicants include state, county, city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations other than federally recognized governments; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (excluding institutions of higher education where specified); for-profit organizations other than small businesses; and small businesses. The opportunity also highlights additional eligible categories such as Alaska Native and Native Hawaiian Serving Institutions; Asian American, Native American, and Pacific Islander Serving Institutions (AANAPISIs); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); faith-based or community-based organizations; eligible federal agencies; regional organizations; U.S. territories or possessions; and even non-domestic (non-U.S.) entities (foreign organizations). Taken together, this signals an intent to encourage participation from a wide range of research environments, including institutions that serve underrepresented populations and organizations positioned to study MODS across diverse pediatric settings.
Overall, the opportunity is essentially a call for focused, high-impact early-stage research that clarifies what drives pediatric MODS, how it can be predicted or detected, and what interventions or management strategies might improve outcomes. The emphasis is on filling gaps in knowledge that currently limit prevention and treatment, producing results that can be scaled into larger, more definitive studies, and ultimately helping clinicians reduce the burden of MODS for critically ill children.Apply for PAR 18 095
- The National Institutes of Health in the health, income security and social services sector is offering a public funding opportunity titled "Research to Advance the Understanding and Management of the Multiple Organ Dysfunction Syndrome in Children (R03 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.865.
- This funding opportunity was created on 2017-11-06.
- Applicants must submit their applications by 2019-05-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $50,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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FAQs: NIH PAR 18-095 - Research to Advance the Understanding and Management of the Multiple Organ Dysfunction Syndrome in Children (R03 Clinical Trial Optional)
What is this funding opportunity?
This is a National Institutes of Health (NIH) funding opportunity announcement (FOA) PAR 18-095 titled "Research to Advance the Understanding and Management of the Multiple Organ Dysfunction Syndrome in Children (R03 Clinical Trial Optional)." It supports small, targeted research projects intended to move the field forward on pediatric multiple organ dysfunction syndrome (MODS).
What health problem is the FOA focused on?
The FOA focuses on multiple organ dysfunction syndrome (MODS) in children, a serious and often life-threatening condition where multiple organ systems fail during critical illness. MODS is described as a major driver of morbidity and mortality in pediatric care.
What is the main goal of the program?
The central goal is to deepen scientific and clinical understanding of pediatric MODS so researchers can identify better ways to prevent MODS, recognize it earlier, and treat it more effectively.
Why is NIH emphasizing pediatric MODS research in this opportunity?
NIH signals that even though MODS can be common and devastating in pediatric critical care, the evidence base remains limited. The FOA emphasizes a strong need for diverse studies that clarify mechanisms, risk factors, trajectories, and management strategies.
What grant mechanism is used?
This opportunity uses the NIH R03 mechanism, which is designed for exploratory or developmental projects that are smaller in scale than an R01.
What kinds of projects are a good fit for an R03 under this FOA?
The FOA describes the R03 as well-suited for pilot studies, feasibility studies, early-stage hypothesis testing, preliminary data generation, method development, or focused analyses that can quickly answer a defined question and set up a stronger future application.
Is the intention that R03 findings lead to larger NIH grants later?
Yes. NIH indicates the work funded here is intended to inform subsequent R01 proposals, making it relevant for teams that need initial data, proof-of-concept results, or refined approaches before pursuing a larger multi-year grant.
Are clinical trials required?
No. The FOA is labeled "Clinical Trial Optional," meaning applicants may propose clinical trials if appropriate, but they are not required.
If clinical trials are optional, what other study types are allowed?
The FOA notes that non-trial studies can fit the intent, including observational research, translational studies, data-driven analyses, or foundational biological investigations, as long as the work clearly advances understanding or management of pediatric MODS.
What research topics does NIH want to see addressed?
Based on the description, NIH is encouraging studies that clarify MODS mechanisms, risk factors, patient trajectories, and management strategies, with a practical focus on prevention, early recognition, and more effective treatment.
What is the award amount (ceiling) indicated in the source data?
The award ceiling listed in the provided source data is $50,000, signaling an emphasis on modest-budget projects with clearly defined deliverables rather than large, resource-intensive studies.
What is the activity category and CFDA listing mentioned?
The opportunity is described as a discretionary grant program under the Health, Income Security and Social Services activity category and is listed under CFDA 93.865.
What are the key dates shown for this opportunity?
The opportunity record shows a creation date of 2017-11-06 and an original closing date listed as 2019-05-07.
Does the timeline suggest this posting may be historical?
Yes. The closing date listed (2019-05-07) suggests the specific posting may be historical. However, the description still illustrates NIH priorities for pediatric MODS research, including prevention and treatment-oriented knowledge generation.
Who is eligible to apply?
Eligibility is broad. The FOA lists many types of U.S. organizations and government entities as eligible, along with additional categories that broaden participation across research environments.
Which government entities are eligible?
Eligible government applicants include state governments; county governments; city or township governments; special district governments; and independent school districts.
Are higher education institutions eligible?
Yes. Eligible applicants include public and state-controlled institutions of higher education and private institutions of higher education.
Are tribal entities eligible?
Yes. Eligible applicants include federally recognized Native American tribal governments and tribal organizations other than federally recognized governments.
Are nonprofits eligible?
Yes. The eligibility list includes nonprofits with or without 501(c)(3) status (excluding institutions of higher education where specified).
Are for-profit organizations eligible?
Yes. Eligible applicants include for-profit organizations other than small businesses, and small businesses are also listed as eligible.
Are public housing authorities eligible?
Yes. Public housing authorities and Indian housing authorities are listed among eligible applicants.
Are institutions serving underrepresented populations specifically highlighted?
Yes. The FOA highlights additional eligible categories such as Alaska Native and Native Hawaiian Serving Institutions; Asian American, Native American, and Pacific Islander Serving Institutions (AANAPISIs); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); and Tribally Controlled Colleges and Universities (TCCUs).
Are faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations are specifically listed as eligible in the opportunity description.
Are federal agencies eligible?
Yes. The opportunity description includes eligible federal agencies among the listed applicant types.
Are regional organizations and U.S. territories eligible?
Yes. Regional organizations and U.S. territories or possessions are included in the highlighted additional eligible categories.
Are non-U.S. (foreign) organizations eligible?
Yes. The eligibility list includes non-domestic (non-U.S.) entities (foreign organizations).
What is the overall theme of what NIH wants funded here?
This FOA is a call for focused, high-impact early-stage research that clarifies what drives pediatric MODS, how it can be predicted or detected, and what interventions or management strategies might improve outcomes, with the aim of generating results that can be scaled into larger, more definitive studies.
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| Translational Research in Pediatric and Obstetric Pharmacology and Therapeutics (R21 Clinical Trial Optional) Apply for PAR 18 214 Funding Number: PAR 18 214 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $200,000 |
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| NICHD Research Project Grant (R01 - Clinical Trial Required) Apply for PA 18 480 Funding Number: PA 18 480 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: Case Dependent |
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| The Role of Stem/Progenitor Cells in the Pathogenesis and Treatment of Gynecologic Disorders (R01 - Clinical Trial Optional) Apply for RFA HD 19 013 Funding Number: RFA HD 19 013 Agency: National Institutes of Health Category: Health, Income Security and Social Services Funding Amount: $499,999 |
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