Implementing Genomics in Practice (IGNITE) II: Pragmatic Clinical Trials Coordinating Center | RFA HG 17 010

Opportunity Information: Apply for RFA HG 17 010

Implementing Genomics in Practice (IGNITE) II: Pragmatic Clinical Trials Coordinating Center (RFA HG 17 010) is a National Institutes of Health (NIH) funding opportunity aimed at building the central hub for the IGNITE II Pragmatic Clinical Trials Network. The broader IGNITE II effort is designed to move genomic medicine beyond pilot projects and into routine care by running pragmatic clinical trials in real-world health care settings. Those trials are intended to generate practical, generalizable evidence about when genomic interventions actually help patients, what they cost, and how to implement them effectively across different types of clinics and health systems.

The core purpose of the network is to measure the clinical utility and cost-effectiveness of genomic medicine interventions, while also testing how these interventions can be integrated into everyday clinical workflows. A key emphasis is on pragmatic clinical trials, meaning studies that are embedded in typical care environments rather than tightly controlled research-only settings. The goal is to learn not only whether genomic tools work under ideal conditions, but whether they work in the messy reality of busy clinics, diverse patient populations, and varying levels of infrastructure. The network also aims to clarify which kinds of genomic medicine interventions truly require randomized clinical trials and to identify the most effective and efficient ways to run those trials at scale.

This particular FOA focuses specifically on the Coordinating Center (CC), which is intended to serve as the operational and scientific backbone of the network. While the announcement text provided does not spell out every duty, the CC role in a pragmatic trials network typically includes coordinating across multiple participating clinical sites, harmonizing protocols and common data elements, supporting consistent trial operations, facilitating communications and governance, and helping ensure that results are comparable and broadly usable. The Coordinating Center is also positioned to support the production of generalizable knowledge by helping standardize approaches, track progress across studies, and enable network-wide learning.

IGNITE II is structured to include multiple Clinical Groups (CGs), including “enhanced diversity” Clinical Groups, alongside a single Coordinating Center. This FOA runs in parallel with companion announcements that solicit applications for the Clinical Groups (RFA-HG-17-008) and the enhanced diversity Clinical Groups (RFA-HG-17-009). In other words, applicants to this FOA are applying to run the centralized coordinating function, while the companion FOAs cover the on-the-ground clinical research teams that will enroll participants and implement interventions.

The award mechanism is a cooperative agreement, reflecting that NIH expects substantial involvement during the project rather than a more hands-off grant relationship. The activity category is health, and the CFDA number listed is 93.172. The opportunity is categorized as discretionary funding. The original closing date for applications was 2017-11-03, and the FOA was created on 2017-07-25. An award ceiling and expected number of awards are not specified in the provided source details.

Eligibility is broad and includes many common U.S.-based applicant types such as state, county, and local governments; special districts; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized tribal governments; tribal organizations other than federally recognized governments; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations (other than small businesses); small businesses; and other eligible entities. The FOA also highlights additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, regional organizations, eligible federal government agencies, and U.S. territories or possessions. At the same time, it clearly restricts foreign involvement: non-domestic (non-U.S.) entities and foreign institutions are not eligible to apply, non-domestic components of U.S. organizations are not eligible, and foreign components (as defined by NIH policy) are not allowed.

In practical terms, the opportunity is geared toward organizations capable of managing complex, multi-site pragmatic clinical trials in genomic medicine, especially in a way that supports consistent methods across varied health care environments and ensures the evidence generated is broadly applicable. The network-wide emphasis on diverse clinical settings, including enhanced diversity clinical groups, signals that the overall program is meant to produce findings that reflect the full range of patients and care contexts found in real U.S. health systems.

• The National Institutes of Health in the health sector is offering a public funding opportunity titled "Implementing Genomics in Practice (IGNITE) II: Pragmatic Clinical Trials Coordinating Center" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.172.
• This funding opportunity was created on 2017-07-25.
• Applicants must submit their applications by 2017-11-03. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

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