Opportunity Information: Apply for PAS 22 206
The NIH HEAL Initiative funding opportunity PAS 22-206 supports K01 Career Development Awards focused on building early career expertise in implementation science for substance use prevention and treatment, with a required clinical trial component. It is designed for early career researchers and early career clinicians who already have a foundational background in addiction and want structured career development that combines mentored training with an applied research project. The central idea is not only to study what works in addiction-related care, but to learn and test the methods that help evidence-based practices get adopted, delivered with quality, sustained over time, and scaled in real-world settings where overdose prevention and treatment actually happen.
Applicants are expected to propose a career development plan that deliberately builds implementation science skills, along with a research project that uses those skills in practice. The research must align with at least one of four priority domains from the HHS Overdose Prevention Strategy: primary prevention (including appropriate opioid prescribing), opioid use disorder (OUD) treatment, harm reduction, and recovery support services. In practical terms, projects could focus on improving uptake of safer prescribing practices, increasing access to medications for OUD, strengthening delivery of harm reduction interventions, or improving implementation of recovery supports across clinical and community systems. The award’s broader goal is workforce-building: creating a pipeline of implementation researchers who can meaningfully contribute to resolving the overdose crisis, raise the quality of addiction care more broadly, and mature into future implementation science leaders and mentors.
This opportunity is issued as a discretionary grant under NIH, within activity categories spanning education and health, and is associated with multiple CFDA numbers (93.393, 93.394, 93.395, 93.396, 93.399). The listing indicates an award ceiling of $275,000. The original closing date is 2025-11-12, and the opportunity was created on 2022-07-14. While the synopsis does not specify the number of expected awards, the emphasis is clearly on supporting individual career development trajectories through protected time, mentorship, and a coherent training-and-research package centered on implementation science approaches applied to overdose-related priorities.
Eligibility is broad and includes many types of organizations that could host and support a K01 candidate. Eligible applicants include state, county, and city/township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; Native American tribal organizations that are not federally recognized; public housing authorities and Indian housing authorities; nonprofits with and without 501(c)(3) status (excluding institutions of higher education in those nonprofit categories); for-profit organizations other than small businesses; small businesses; and additional “other” entities. The announcement also highlights additional eligible applicant types such as Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISIs); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); faith-based or community-based organizations; eligible federal agencies; regional organizations; tribal governments other than federally recognized ones; non-U.S. entities (foreign organizations); and U.S. territories or possessions. This breadth signals an interest in reaching diverse institutions and real-world service settings where implementation challenges are most pressing, including community-based and underserved contexts.
Overall, this FOA is best read as a career-building mechanism: it funds a mentored pathway for promising early career professionals to gain formal and applied training in implementation science, then use that training to run a clinically grounded project that addresses one or more overdose-prevention priorities. The intended end result is not just a single study, but a sustainable research career that strengthens how prevention, treatment, harm reduction, and recovery supports are implemented and maintained in everyday practice.Apply for PAS 22 206
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "HEAL Initiative: Career Development Awards in Implementation Science for Substance Use Prevention and Treatment (K01 - Clinical Trial Required)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393, 93.394, 93.395, 93.396, 93.399.
- This funding opportunity was created on 2022-07-14.
- Applicants must submit their applications by 2025-11-12. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $275,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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| Galvanizing Health Equity Through Novel and Diverse Educational Resources (GENDER) Research Education R25 (R25 Clinical Trial Not Allowed) Apply for RFA OD 22 015 Funding Number: RFA OD 22 015 Agency: National Institutes of Health Category: Education, Health Funding Amount: $150,000 |
| Limited Competition: Cancer Immune Monitoring and Analysis Centers (CIMACs) and Cancer Immunologic Data Center (CIDC) (U24 Clinical Trial Not Allowed) Apply for RFA CA 22 038 Funding Number: RFA CA 22 038 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| The Early Detection Research Network: Clinical Validation Centers (U01 Clinical Trial Optional) Apply for RFA CA 22 039 Funding Number: RFA CA 22 039 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| The Early Detection Research Network: Biomarker Characterization Centers (U2C Clinical Trial Not Allowed) Apply for RFA CA 22 040 Funding Number: RFA CA 22 040 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Expanding Collaborative Implementation Science to Address Social and Structural Determinants of Health and Improve HIV Outcomes (R24 Clinical Trial Not Allowed) Apply for RFA MH 22 191 Funding Number: RFA MH 22 191 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Expanding Collaborative Implementation Science to Address Social and Structural Determinants of Health and Improve HIV Outcomes (R01 Clinical Trial Required) Apply for RFA MH 22 190 Funding Number: RFA MH 22 190 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Biology of Bladder Cancer (R01 Clinical Trial Optional) Apply for PAR 22 218 Funding Number: PAR 22 218 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Cellular and Molecular Mechanisms of Prion-Like Aggregate Seeding, Propagation, and Neurotoxicity in AD/ADRD (R01 Clinical Trial Not Allowed) Apply for PAR 23 023 Funding Number: PAR 23 023 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| HEAL Initiative: Research Studies to Develop and Implement Interventions to Prevent Opioid Misuse in Community Health Centers (R61/R33 Clinical Trial Required) Apply for RFA DA 23 048 Funding Number: RFA DA 23 048 Agency: National Institutes of Health Category: Education, Health Funding Amount: $750,000 |
| Biology of Bladder Cancer (R21 Clinical Trial Optional) Apply for PAR 22 219 Funding Number: PAR 22 219 Agency: National Institutes of Health Category: Education, Health Funding Amount: $275,000 |
| NCI Outstanding Investigator Award (R35 Clinical Trial Optional) Apply for RFA CA 22 045 Funding Number: RFA CA 22 045 Agency: National Institutes of Health Category: Education, Health Funding Amount: $600,000 |
| HEAL Initiative: Therapeutics Development for Opioid Use Disorder in Patients with Co-occurring Mental Disorders (UG3/UH3 - Clinical Trial Optional) Apply for RFA DA 23 049 Funding Number: RFA DA 23 049 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Global Implementation Science for Equitable Cancer Control (GlobalISE Cancer Control, U54 Clinical Trial Optional) Apply for RFA CA 22 019 Funding Number: RFA CA 22 019 Agency: National Institutes of Health Category: Education, Health Funding Amount: $750,000 |
| HEAL Initiative: Oral Complications Arising from Pharmacotherapies to Treat Opioid Use Disorders (R01 Clinical Trial Not Allowed) Apply for RFA DE 23 015 Funding Number: RFA DE 23 015 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| HEAL Initiative: Oral Complications Arising from Pharmacotherapies to Treat Opioid Use Disorders (R21 Clinical Trial Not Allowed) Apply for RFA DE 23 016 Funding Number: RFA DE 23 016 Agency: National Institutes of Health Category: Education, Health Funding Amount: $250,000 |
| NIDA REI: Addressing Racial Equity in Substance Use and Addiction Outcomes Through Community-Engaged Research at Minority Serving Institutions (R01 Clinical Trial Optional) Apply for RFA DA 23 032 Funding Number: RFA DA 23 032 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| NIDA REI: Addressing Racial Equity in Substance Use and Addiction Outcomes Through Community-Engaged Research (R01 Clinical Trial Optional) Apply for RFA DA 23 013 Funding Number: RFA DA 23 013 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| NIDA REI: Research on Neurocognitive Mechanisms Underlying the Impact of Structural Racism on the Substance Use Trajectory (R61/R33 Clinical Trial Optional) Apply for RFA DA 23 028 Funding Number: RFA DA 23 028 Agency: National Institutes of Health Category: Education, Health Funding Amount: $500,000 |
| NIDA REI: Racial Equity Visionary Award Program for Research on Substance Use and Racial Equity (DP1 Clinical Trial Optional) Apply for RFA DA 23 026 Funding Number: RFA DA 23 026 Agency: National Institutes of Health Category: Education, Health Funding Amount: $700,000 |
| NIDA REI: Research at Minority Serving Institutions on Neurocognitive Mechanisms Underlying the Impact of Structural Racism on the Substance Use Trajectory (R61/R33 Clinical Trial Optional) Apply for RFA DA 23 029 Funding Number: RFA DA 23 029 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
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