Opportunity Information: Apply for PA 18 394
The Midcareer Investigator Award in Patient-Oriented Research (Parent K24 - No Independent Clinical Trials), funding opportunity number PA-18-394, is an NIH career development grant designed to strengthen the clinical research workforce by supporting established, mid-career clinician-investigators. Its central goal is to buy protected time for experienced patient-oriented researchers, typically at the associate professor level (or equivalent), so they can both continue advancing their own patient-oriented research programs and devote substantial effort to mentoring the next generation of clinical researchers. The mentoring emphasis is a defining feature of the K24: awardees are expected to serve as research mentors primarily for clinical residents, clinical fellows, and/or junior clinical faculty, helping them develop rigorous research skills and progress toward independent research careers.
This opportunity specifically targets patient-oriented research (POR), meaning research that directly involves human subjects and is conducted with the intent of understanding disease mechanisms, developing or testing interventions, improving clinical care, or otherwise generating knowledge derived from direct interaction with people or identifiable human data/specimens in a clinical context. The parenthetical designation "No Independent Clinical Trials" indicates that the award is not intended for applicants proposing to lead an independent clinical trial as the main component of the K24 application. In practice, the focus is on supporting the investigator's protected time and mentoring activities in a patient-oriented research environment rather than funding a standalone trial run by the K24 awardee as the trial's independent leader.
From an institutional eligibility standpoint, the applicant organizations that can submit applications are broad and include many types of U.S.-based entities. Eligible applicants listed include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; nonprofit organizations (both with and without 501(c)(3) IRS status, other than institutions of higher education); for-profit organizations (other than small businesses); small businesses; and certain tribal entities, including federally recognized Native American tribal governments, public housing authorities/Indian housing authorities, and Native American tribal organizations other than federally recognized governments. The announcement also highlights additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), eligible federal agencies, faith-based or community-based organizations, regional organizations, Indian/Native American tribal governments other than federally recognized, and U.S. territories or possessions.
At the same time, there are important restrictions related to foreign participation. Non-domestic (non-U.S.) entities (foreign institutions) are not eligible to apply as the applicant organization, and non-domestic components of U.S. organizations are not eligible. However, "foreign components" are allowed when defined and justified under NIH policy, meaning parts of the research or collaboration may occur outside the U.S. under NIH rules, even though the primary applicant institution must be domestic.
Administratively, this is a discretionary grant mechanism offered by the National Institutes of Health under the "Grant" funding instrument type, and it falls under an activity category associated with education, environment, and health. The program is associated with multiple CFDA numbers (93.113, 93.173, 93.213, 93.233, 93.242, 93.273, 93.279, 93.361, 93.837, 93.838, 93.839, 93.840, 93.855, 93.866), reflecting that different NIH institutes and centers participating in the parent K24 may align the award with different program authorities. The posting shows a creation date of November 22, 2017, and an original closing date of January 7, 2019. The excerpt provided does not specify an award ceiling or the expected number of awards, which often means those details may vary by NIH institute/center and by fiscal year allocations rather than being fixed in the parent announcement.
Overall, this K24 opportunity is best understood as a midcareer "time and mentoring" award: it is aimed at clinicians who are already productive patient-oriented investigators and who can demonstrate both a strong research trajectory and a robust plan to mentor clinical trainees and junior faculty. The NIH intent is to create sustained capacity in patient-oriented research by freeing up experienced investigators to lead by example, build mentoring pipelines, and maintain high-quality clinical research programs without the expectation that the K24 itself serves as a vehicle for an independent clinical trial led by the awardee.Apply for PA 18 394
- The National Institutes of Health in the education, environment, health sector is offering a public funding opportunity titled "Midcareer Investigator Award in Patient-Oriented Research (Parent K24 - No Independent Clinical Trials)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.173, 93.213, 93.233, 93.242, 93.273, 93.279, 93.361, 93.837, 93.838, 93.839, 93.840, 93.855, 93.866.
- This funding opportunity was created on 2017-11-22.
- Applicants must submit their applications by 2019-01-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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| NIH Exploratory/Developmental Research Grant Program ( Parent R21 Clinical Trial Not Allowed) Apply for PA 18 489 Funding Number: PA 18 489 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $200,000 |
| Ruth L. Kirschstein National Research Service Award (NRSA) Individual Senior Fellowship (Parent F33) Apply for PA 18 672 Funding Number: PA 18 672 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Innovative Basic Research on Adducts in Cancer Risk Identification and Prevention (R01 Clinical Trial Not Allowed) Apply for PAR 18 704 Funding Number: PAR 18 704 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Innovative Basic Research on Adducts in Cancer Risk Identification and Prevention (R21 Clinical Trial Not Allowed) Apply for PAR 18 703 Funding Number: PAR 18 703 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $200,000 |
| Electronic Nicotine Delivery Systems (ENDS): Basic Mechanisms of Health Effects (R01 - Clinical Trial Not Allowed) Apply for PAR 18 845 Funding Number: PAR 18 845 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Electronic Nicotine Delivery Systems (ENDS): Basic Mechanisms of Health Effects (R21 - Clinical Trial Not Allowed) Apply for PAR 18 846 Funding Number: PAR 18 846 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Superfund Hazardous Substance Research and Training Program (P42 Clinical Trial Optional) Apply for RFA ES 18 002 Funding Number: RFA ES 18 002 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $1,750,000 |
| Emerging Global Leader Award (K43 Independent Clinical Trial Required) Apply for PAR 19 038 Funding Number: PAR 19 038 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Countermeasures Against Chemical Threats (CounterACT): Identification of Therapeutic Lead Compounds (U01 Clinical Trial Not Allowed) Apply for PAR 19 039 Funding Number: PAR 19 039 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $300,000 |
| Countermeasures Against Chemical Threats (CounterACT): Optimization of Therapeutic Lead Compounds (U01 Clinical Trial Optional) Apply for PAR 19 040 Funding Number: PAR 19 040 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Promoting Research on Music and Health: Fundamentals and Applications (R21 Clinical Trials Optional) Apply for RFA NS 19 009 Funding Number: RFA NS 19 009 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Immuno-Oncology Translation Network (IOTN): Cancer Immunoprevention Research Projects (UG3/UH3) Apply for RFA CA 19 012 Funding Number: RFA CA 19 012 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $500,000 |
| Emerging Global Leader Award (K43 Independent Clinical Trial Required) Apply for PAR 19 051 Funding Number: PAR 19 051 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| Research Project Grant (Parent R01 Clinical Trial Required) Apply for PA 19 055 Funding Number: PA 19 055 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| NIH Exploratory/Developmental Research Grant Program (Parent R21 Clinical Trial Not Allowed) Apply for PA 19 053 Funding Number: PA 19 053 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $200,000 |
| NIH Exploratory/Developmental Research Grant Program (Parent R21 Clinical Trial Required) Apply for PA 19 054 Funding Number: PA 19 054 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $200,000 |
| NIH Small Research Grant Program (Parent R03 Clinical Trial Not Allowed) Apply for PA 19 052 Funding Number: PA 19 052 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $50,000 |
| NIH Research Project Grant (Parent R01 Basic Experimental Studies with Humans Required) Apply for PA 19 091 Funding Number: PA 19 091 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
| NIH Exploratory/Developmental Research Grant Program (Parent R21 Basic Experimental Studies with Humans Required) Apply for PA 19 092 Funding Number: PA 19 092 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: $200,000 |
| Midcareer Investigator Award in Patient-Oriented Research (Parent K24 - Independent Basic Experimental Studies with Humans Required) Apply for PA 19 088 Funding Number: PA 19 088 Agency: National Institutes of Health Category: Education, Environment, Health Funding Amount: Case Dependent |
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